Excel Interop : System.Runtime.InteropServices.COMException (0x800A03EC): Microsoft Office Excel cannot access the file

Introduction

System.Runtime.InteropServices.COMException (0x800A03EC): Microsoft Office Excel cannot access the file 'D:\sunil\sunil.xls. There are several possible reasons: • the file name or path does not exist. •

This error occur on widows server 2008 r2 64 bit

 

Solution

Create folder Desktop.

Create directory "C:\Windows\SysWOW64\config\systemprofile\Desktop” (for 64 bit Windows) or "C:\Windows\System32\config\systemprofile\Desktop” (for 32 bit Windows)